95560

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95560

Fluka

 

8-Methoxypsoralen

BioChemika, for fluorescence, ≥99.0% (HPLC)

Synonym:8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin
CAS Number:298-81-7
Linear Formula:C12H8O4
Molecular Weight:216.19
Beilstein Registry Number:196453
EC Number:206-066-9
MDL number:MFCD00005009

Description

Biochem/physiol Actions8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].
Other NotesProperties1; Photochemical reactions of 8-methoxypsoralen with calf thymus DNA2

Properties

gradefor fluorescence
product lineBioChemika
assay≥99.0% (HPLC)
loss≤1% loss on drying
mp142-148 °C
 148-150 °C(lit.)

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard CodesXn
Risk Statements22-43
Safety Statements36/37
WGK Germany3
RTECSLV1400000

References

Cited Reference1. M.A. Loutfy, M.A. Hassan Anal. Profiles Drug Subst. 9, 455, (1980)
 2. J.W. Tessman et al. Biochemistry 24, 1669, (1985) Abstract
MerckMerck 13,6018
BeilsteinBeil. 19,V,6,15
referenceAldrich MSDS 1, 1196:C / Corp MSDS 1 (2), 2272:B / FT-IR 1 (2), 684:D / FT-IR 2 (3), 3620:A / FT-NMR 1 (3), 173:B / NMR-Reference 2 (2), 554:A / RegBook 1 (2), 2433:D / Sax 6, 2738 / Sigma FT-IR 1 (2), 716:C / Structure Index 1, 385:E:6